Dr. Nicolas Tchitchek
Associate Professor in Systems Immunology
Research unit "Immunology-Immunopathology-Immunotherapy" (Inserm UMR-S 959)
Hospital of the Pitié-Salpêtrière — Sorbonne University, Paris, France

Nicolas Tchitchek's Homepage - Publications

Publications of Dr. Nicolas Tchitchek. Publications of Dr. Nicolas Tchitchek are available via pubmed and google scholar

Publications as leading author or as principal investigator

[46] Leite Pereira A, Bitoun S, Paoletti A, Nocturne G, Marcos Lopez E, Cosma A, Le Grand R, Mariette X, and Tchitchek N. Characterization of Phenotypes and Functional Activities of Leukocytes From Rheumatoid Arthritis Patients by Mass Cytometry. Front Immunol. 10:2384. doi:10.3389/fimmu.2019.02384 (2019)

[44] Leite Pereira A*, Tchitchek N*, Lambotte O, Le Grand R, and Cosma A. Characterization of Leukocytes From HIV-ART Patients Using Combined Cytometric Profiles of 72 Cell Markers. Front Immunol. 10:1777. doi:10.3389/fimmu.2019.01777 (2019)

[43] Nugeyre MT*, Tchitchek N*, Adapen C, Cannou C, Contreras V, Benjelloun F, Ravel J, Le Grand R, Marlin R, and Menu E. Dynamics of Vaginal and Rectal Microbiota Over Several Menstrual Cycles in Female Cynomolgus Macaques. Front Cell Infect Microbiol. 9:188. doi:10.3389/fcimb.2019.00188 (2019)

[39] Leite Pereira A, Lambotte O, Le Grand R, Cosma A, and Tchitchek N. CytoBackBone: an algorithm for merging of phenotypic information from different cytometric profiles. Bioinformatics. 35(20):4187-4189. doi:10.1093/bioinformatics/btz212 (2019)

[29] Platon L, Pejoski D, Gautreau G, Targat B, Le Grand R, Beignon AS, and Tchitchek N. A computational approach for phenotypic comparisons of cell populations in high-dimensional cytometry data. Methods. 132:66-75. doi:S1046-2023(17)30045-2 (2017)

[23] Gautreau G, Pejoski D, Le Grand R, Cosma A, Beignon AS, and Tchitchek N. SPADEVizR: an R package for visualization, analysis and integration of SPADE results. Bioinformatics. 33(5):779-781. doi:10.1093/bioinformatics/btw708 (2016)

[18] Herbert F*, Tchitchek N*, Bansal D, Jacques J, Pathak S, Bécavin C, Fesel C, Dalko E, Cazenave PA, Preda C, Ravindran B, Sharma S, Das B, and Pied S. Evidence of IL-17, IP-10, and IL-10 involvement in multiple-organ dysfunction and IL-17 pathway in acute renal failure associated to Plasmodium falciparum malaria. J Transl Med. 13:369. doi:10.1186/s12967-015-0731-6 (2015)

[17] Rasmussen AL*, Tchitchek N*, Safronetz D, Carter VS, Williams CM, Haddock E, Korth MJ, Feldmann H, and Katze MG. Delayed inflammatory and cell death responses are associated with reduced pathogenicity in Lujo virus-infected cynomolgus macaques. J. Virol.. 89(5):2543-52. doi:10.1128/JVI.02246-14 (2014)

[16] Tchitchek N, Safronetz D, Rasmussen AL, Martens C, Virtaneva K, Porcella SF, Feldmann H, Ebihara H, and Katze MG. Sequencing, annotation and analysis of the Syrian hamster (Mesocricetus auratus) transcriptome. PLoS ONE. 9(11):e112617. doi:10.1371/journal.pone.0112617 (2014)

[11] Tchitchek N, Eisfeld AJ, Tisoncik-Go J, Josset L, Gralinski LE, Bécavin C, Tilton SC, Webb-Robertson BJ, Ferris MT, Totura AL, Li C, Neumann G, Metz TO, Smith RD, Waters KM, Baric R, Kawaoka Y, and Katze MG. Specific mutations in H5N1 mainly impact the magnitude and velocity of the host response in mice. BMC Syst Biol. 7:69. doi:10.1186/1752-0509-7-69 (2013)

[07] Tchitchek N, Dzib JF, Targat B, Noth S, Benecke A, and Lesne A. CDS: a fold-change based statistical test for concomitant identification of distinctness and similarity in gene expression analysis. Genomics Proteomics Bioinformatics. 10(3):127-35. doi:10.1016/j.gpb.2012.06.002 (2012)

[06] Tchitchek N, Jacquelin B, Wincker P, Dossat C, Silva CD, Weissenbach J, Blancher A, Müller-Trutwin M, and Benecke A. Expression sequence tag library derived from peripheral blood mononuclear cells of the chlorocebus sabaeus. BMC Genomics. 13:279. doi:10.1186/1471-2164-13-279 (2012)

[05] Rasmussen AL*, Tchitchek N*, Susnow NJ, Krasnoselsky AL, Diamond DL, Yeh MM, Proll SC, Korth MJ, Walters KA, Lederer S, Larson AM, Carithers RL, Benecke A, and Katze MG. Early transcriptional programming links progression to hepatitis C virus-induced severe liver disease in transplant patients. Hepatology. 56(1):17-27. doi:10.1002/hep.25612 (2012)

* These authors equaly contributed to the works

Publications from collaborative works

[49] Gonnet J, Poncelet L, Meriaux C, Gonçalves E, Weiss L, Tchitchek N, Pedruzzi E, Soria A, Boccara D, Vogt A, Bonduelle O, Hamm G, Ait-Belkacem R, Stauber J, Fournier I, Wisztorski M, and Combadiere B. Mechanisms of innate events during skin reaction following intradermal injection of seasonal influenza vaccine. J Proteomics. NA:103670. doi:S1874-3919(20)30038-5 (2020)

[48] Coindre S, Tchitchek N, Alaoui L, Vaslin B, Bourgeois C, Goujard C, Lecuroux C, Bruhns P, Le Grand R, Beignon AS, Lambotte O, and Favier B. Mass Cytometry Analysis Reveals Complex Cell-State Modifications of Blood Myeloid Cells During HIV Infection. Front Immunol. 10:2677. doi:10.3389/fimmu.2019.02677 (2019)

[47] Serguera C, Stimmer L, Fovet CM, Horellou P, Contreras V, Tchitchek N, Massonneau J, Leroy C, Perrin A, Flament J, Hantraye P, Demilly J, Marignier R, Chrétien P, Hart B, Boutonnat J, Adam C, Le-Grand R, and Deiva K. Anti-MOG autoantibodies pathogenicity in children and macaques demyelinating diseases. J Neuroinflammation. 16(1):244. doi:10.1186/s12974-019-1637-7 (2019)

[45] Fovet CM, Stimmer L, Contreras V, Horellou P, Hubert A, Seddiki N, Chapon C, Tricot S, Leroy C, Flament J, Massonneau J, Tchitchek N, Zurawski S, Klucar P, Hantraye P, Deiva K, Zurawski G, Oh S, Le Grand R, and Serguera C. Intradermal vaccination prevents anti-MOG autoimmune encephalomyelitis in macaques. EBioMedicine. 47:492-505. doi:S2352-3964(19)30574-2 (2019)

[42] Shiina T, Suzuki S, Congy-Jolivet N, Aarnink A, Garchon HJ, Dereuddre-Bosquet N, Vaslin B, Tchitchek N, Desjardins D, Autran B, Lambotte O, Theodorou I, Le Grand R, and Blancher A. Cynomolgus macaque IL37 polymorphism and control of SIV infection. Sci Rep. 9(1):7981. doi:10.1038/s41598-019-44235-x (2019)

[41] Mauffrey P, Tchitchek N, Barroca V, Bemelmans AP, Firlej V, Allory Y, Roméo PH, and Magnon C. Progenitors from the central nervous system drive neurogenesis in cancer. Nature. 569(7758):672-678. doi:10.1038/s41586-019-1219-y (2019)

[40] Marlin R, Nugeyre MT, Tchitchek N, Parenti M, Lefebvre C, Hocini H, Benjelloun F, Cannou C, Nozza S, Dereuddre-Bosquet N, Levy Y, Barré-Sinoussi F, Scarlatti G, Le Grand R, and Menu E. Seminal Plasma Exposures Strengthen Vaccine Responses in the Female Reproductive Tract Mucosae. Front Immunol. 10:430. doi:10.3389/fimmu.2019.00430 (2019)

[38] Tissier R, Hocini H, Tchitchek N, Deye N, Legriel S, Pichon N, Daubin C, Hermine O, Carli P, Vivien B, Tréluyer JM, Lefebvre C, Tisserand P, Dubois-Randé JL, Berdeaux A, Ghaleh B, Lelièvre JD, Levy Y, and Cariou A. Early blood transcriptomic signature predicts patients' outcome after out-of-hospital cardiac arrest. Resuscitation. 138:222-232. doi:S0300-9572(19)30072-3 (2019)

[37] Gonçalves E, Bonduelle O, Soria A, Loulergue P, Rousseau A, Cachanado M, Bonnabau H, Thiebaut R, Tchitchek N, Behillil S, van der Werf S, Vogt A, Simon T, Launay O, and Combadière B. Innate gene signature distinguishes humoral versus cytotoxic responses to influenza vaccination. J. Clin. Invest.. 129(5):1960-1971. doi:10.1172/JCI125372 (2019)

[36] Palgen JL, Tchitchek N, Huot N, Elhmouzi-Younes J, Lefebvre C, Rosenbaum P, Dereuddre-Bosquet N, Martinon F, Hocini H, Cosma A, Müller-Trutwin M, Lévy Y, Le Grand R, and Beignon AS. NK cell immune responses differ after prime and boost vaccination. J. Leukoc. Biol.. 105(5):1055-1073. doi:10.1002/JLB.4A1018-391RR (2019)

[35] Leite Pereira A, Tchitchek N, Marcos Lopez E, Lambotte O, Le Grand R, and Cosma A. A high-resolution mass cytometry analysis reveals a delay of cytokines production after TLR4 or TLR7/8 engagements in HIV-1 infected humans. Cytokine. 111:97-105. doi:S1043-4666(18)30353-3 (2018)

[34] Rosenbaum P, Tchitchek N, Joly C, Stimmer L, Hocini H, Dereuddre-Bosquet N, Beignon AS, Chapon C, Levy Y, Le Grand R, and Martinon F. Molecular and Cellular Dynamics in the Skin, the Lymph Nodes, and the Blood of the Immune Response to Intradermal Injection of Modified Vaccinia Ankara Vaccine. Front Immunol. 9:870. doi:10.3389/fimmu.2018.00870 (2018)

[33] Coindre S, Tchitchek N, Alaoui L, Vaslin B, Bourgeois C, Goujard C, Avettand-Fenoel V, Lecuroux C, Bruhns P, Le Grand R, Beignon AS, Lambotte O, and Favier B. Mass Cytometry Analysis Reveals the Landscape and Dynamics of CD32a+ CD4+ T Cells From Early HIV Infection to Effective cART. Front Immunol. 9:1217. doi:10.3389/fimmu.2018.01217 (2018)

[32] Palgen JL, Tchitchek N, Elhmouzi-Younes J, Delandre S, Namet I, Rosenbaum P, Dereuddre-Bosquet N, Martinon F, Cosma A, Lévy Y, Le Grand R, and Beignon AS. Prime and Boost Vaccination Elicit a Distinct Innate Myeloid Cell Immune Response. Sci Rep. 8(1):3087. doi:10.1038/s41598-018-21222-2 (2018)

[31] Echebli N, Tchitchek N, Dupuy S, Bruel T, Peireira Bittencourt Passaes C, Bosquet N, Le Grand R, Bourgeois C, Favier B, Cheynier R, Lambotte O, and Vaslin B. Stage-specific IFN-induced and IFN gene expression reveal convergence of type I and type II IFN and highlight their role in both acute and chronic stage of pathogenic SIV infection. PLoS ONE. 13(1):e0190334. doi:10.1371/journal.pone.0190334 (2018)

[28] Marlin R, Nugeyre MT, Tchitchek N, Parenti M, Hocini H, Benjelloun F, Cannou C, Dereuddre-Bosquet N, Levy Y, Barré-Sinoussi F, Scarlatti G, Le Grand R, and Menu E. Modified Vaccinia Virus Ankara Vector Induces Specific Cellular and Humoral Responses in the Female Reproductive Tract, the Main HIV Portal of Entry. J. Immunol.. 199(5):1923-1932. doi:10.4049/jimmunol.1700320 (2017)

[27] Elhmouzi-Younes J, Palgen JL, Tchitchek N, Delandre S, Namet I, Bodinham CL, Pizzoferro K, Lewis DJM, Le Grand R, Cosma A, and Beignon AS. In depth comparative phenotyping of blood innate myeloid leukocytes from healthy humans and macaques using mass cytometry. Cytometry A. 91(10):969-982. doi:10.1002/cyto.a.23107 (2017)

[26] Roques P, Ljungberg K, Kümmerer BM, Gosse L, Dereuddre-Bosquet N, Tchitchek N, Hallengärd D, García-Arriaza J, Meinke A, Esteban M, Merits A, Le Grand R, and Liljeström P. Attenuated and vectored vaccines protect nonhuman primates against Chikungunya virus. JCI Insight. 2(6):e83527. doi:10.1172/jci.insight.83527 (2017)

[25] Bécavin C, Koutero M, Tchitchek N, Cerutti F, Lechat P, Maillet N, Hoede C, Chiapello H, Gaspin C, and Cossart P. Listeriomics: an Interactive Web Platform for Systems Biology of Listeria. mSystems. 2(2). doi:e00186-16 (2017)

[24] Lamart S, Griffiths NM, Tchitchek N, Angulo JF, and Van der Meeren A. Analysis methodology and development of a statistical tool for biodistribution data from internal contamination with actinides. J Radiol Prot. 37(1):296-308. doi:10.1088/1361-6498/37/1/296 (2017)

[22] Bodez D, Hocini H, Tchitchek N, Tisserand P, Benhaiem N, Barau C, Kharoubi M, Guellich A, Guendouz S, Radu C, Couetil JP, Ghaleh B, Dubois-Randé JL, Teiger E, Hittinger L, Levy Y, and Damy T. Myocardial Gene Expression Profiling to Predict and Identify Cardiac Allograft Acute Cellular Rejection: The GET-Study. PLoS ONE. 11(11):e0167213. doi:10.1371/journal.pone.0167213 (2016)

[21] Dalko E, Tchitchek N, Pays L, Herbert F, Cazenave PA, Ravindran B, Sharma S, Nataf S, Das B, and Pied S. Erythropoietin Levels Increase during Cerebral Malaria and Correlate with Heme, Interleukin-10 and Tumor Necrosis Factor-Alpha in India. PLoS ONE. 11(7):e0158420. doi:10.1371/journal.pone.0158420 (2016)

[20] Pejoski D, Tchitchek N, Rodriguez Pozo A, Elhmouzi-Younes J, Yousfi-Bogniaho R, Rogez-Kreuz C, Clayette P, Dereuddre-Bosquet N, Lévy Y, Cosma A, Le Grand R, and Beignon AS. Identification of Vaccine-Altered Circulating B Cell Phenotypes Using Mass Cytometry and a Two-Step Clustering Analysis. J. Immunol.. 196(11):4814-31. doi:10.4049/jimmunol.1502005 (2016)

[19] Forero A, Tisoncik-Go J, Watanabe T, Zhong G, Hatta M, Tchitchek N, Selinger C, Chang J, Barker K, Morrison J, Berndt JD, Moon RT, Josset L, Kawaoka Y, and Katze MG. The 1918 Influenza Virus PB2 Protein Enhances Virulence through the Disruption of Inflammatory and Wnt-Mediated Signaling in Mice. J. Virol.. 90(5):2240-53. doi:10.1128/JVI.02974-15 (2015)

[15] Morrison J, Josset L, Tchitchek N, Chang J, Belser JA, Swayne DE, Pantin-Jackwood MJ, Tumpey TM, and Katze MG. H7N9 and other pathogenic avian influenza viruses elicit a three-pronged transcriptomic signature that is reminiscent of 1918 influenza virus and is associated with lethal outcome in mice. J. Virol.. 88(18):10556-68. doi:10.1128/JVI.00570-14 (2014)

[14] Josset L, Tchitchek N, Gralinski LE, Ferris MT, Eisfeld AJ, Green RR, Thomas MJ, Tisoncik-Go J, Schroth GP, Kawaoka Y, Manuel de Villena FP, Baric RS, Heise MT, Peng X, and Katze MG. Annotation of long non-coding RNAs expressed in collaborative cross founder mice in response to respiratory virus infection reveals a new class of interferon-stimulated transcripts. RNA Biol. 11(7):875-90. doi:10.4161/rna.29442 (2014)

[13] Aevermann BD, Pickett BE, Kumar S, Klem EB, Agnihothram S, Askovich PS, Bankhead A, Bolles M, Carter V, Chang J, Clauss TR, Dash P, Diercks AH, Eisfeld AJ, Ellis A, Fan S, Ferris MT, Gralinski LE, Green RR, Gritsenko MA, Hatta M, Heegel RA, Jacobs JM, Jeng S, Josset L, Kaiser SM, Kelly S, Law GL, Li C, Li J, Long C, Luna ML, Matzke M, McDermott J, Menachery V, Metz TO, Mitchell H, Monroe ME, Navarro G, Neumann G, Podyminogin RL, Purvine SO, Rosenberger CM, Sanders CJ, Schepmoes AA, Shukla AK, Sims A, Sova P, Tam VC, Tchitchek N, Thomas PG, Tilton SC, Totura A, Wang J, Webb-Robertson BJ, Wen J, Weiss JM, Yang F, Yount B, Zhang Q, McWeeney S, Smith RD, Waters KM, Kawaoka Y, Baric R, Aderem A, Katze MG, and Scheuermann RH. A comprehensive collection of systems biology data characterizing the host response to viral infection. Sci Data. 1:140033. doi:10.1038/sdata.2014.33 (2014)

[12] Mitchell HD, Eisfeld AJ, Sims AC, McDermott JE, Matzke MM, Webb-Robertson BJ, Tilton SC, Tchitchek N, Josset L, Li C, Ellis AL, Chang JH, Heegel RA, Luna ML, Schepmoes AA, Shukla AK, Metz TO, Neumann G, Benecke AG, Smith RD, Baric RS, Kawaoka Y, Katze MG, and Waters KM. A network integration approach to predict conserved regulators related to pathogenicity of influenza and SARS-CoV respiratory viruses. PLoS ONE. 8(7):e69374. doi:10.1371/journal.pone.0069374 (2013)

[10] Watanabe T, Tisoncik-Go J, Tchitchek N, Watanabe S, Benecke AG, Katze MG, and Kawaoka Y. 1918 Influenza virus hemagglutinin (HA) and the viral RNA polymerase complex enhance viral pathogenicity, but only HA induces aberrant host responses in mice. J. Virol.. 87(9):5239-54. doi:10.1128/JVI.02753-12 (2013)

[08] Go JT, Belisle SE, Tchitchek N, Tumpey TM, Ma W, Richt JA, Safronetz D, Feldmann H, and Katze MG. 2009 pandemic H1N1 influenza virus elicits similar clinical course but differential host transcriptional response in mouse, macaque, and swine infection models. BMC Genomics. 13:627. doi:10.1186/1471-2164-13-627 (2012)

[04] Chang ST, Tchitchek N, Ghosh D, Benecke A, and Katze MG. A chemokine gene expression signature derived from meta-analysis predicts the pathogenicity of viral respiratory infections. BMC Syst Biol. 5:202. doi:10.1186/1752-0509-5-202 (2011)

[03] Bécavin C, Tchitchek N, Mintsa-Eya C, Lesne A, and Benecke A. Improving the efficiency of multidimensional scaling in the analysis of high-dimensional data using singular value decomposition. Bioinformatics. 27(10):1413-21. doi:10.1093/bioinformatics/btr143 (2011)

[02] Fernandes-Rosa FL, Hubert EL, Fagart J, Tchitchek N, Gomes D, Jouanno E, Benecke A, Rafestin-Oblin ME, Jeunemaitre X, Antonini SR, and Zennaro MC. Mineralocorticoid receptor mutations differentially affect individual gene expression profiles in pseudohypoaldosteronism type 1. J. Clin. Endocrinol. Metab.. 96(3):E519-27. doi:10.1210/jc.2010-1486 (2010)

[01] Endt K, Stecher B, Chaffron S, Slack E, Tchitchek N, Benecke A, Van Maele L, Sirard JC, Mueller AJ, Heikenwalder M, Macpherson AJ, Strugnell R, von Mering C, and Hardt WD. The microbiota mediates pathogen clearance from the gut lumen after non-typhoidal Salmonella diarrhea. PLoS Pathog.. 6(9):e1001097. doi:10.1371/journal.ppat.1001097 (2010)

Reviews, book chapters, and editorials

[30] Tchitchek N. Navigating in the vast and deep oceans of high-dimensional biological data. Methods. 132:1-2. doi:S1046-2023(17)30467-X (2017)

[09] Korth MJ, Tchitchek N, Benecke AG, and Katze MG. Systems approaches to influenza-virus host interactions and the pathogenesis of highly virulent and pandemic viruses. Semin. Immunol.. 25(3):228-39. doi:10.1016/j.smim.2012.11.001 (2012)

Other links to my list of publications

My list of publications and the associated papers can also be obtained at: